Actin defects in primary immunodeficiencies (ACTIv)

Primary immunodeficiencies represent a large group of genetic disorders characterized by immune system dysfunction. Patients with immunodeficiencies are particularly susceptible to infections. Recently, some of these immunodeficiencies have been linked to abnormalities in the actin cytoskeleton, a collection of filaments that form the cellular “skeleton” and give cells their mechanical properties. In the immune system, the actin cytoskeleton is also very important for the transmission of signals inside and between the cells. The general aim of the project is to better understand immunodeficiencies that result from defects in the cytoskeleton. The results will deepen our knowledge of these diseases and ultimately enable the development of personalized treatments. The project is led by the University of Strasbourg and is carried out in cooperation with the Universities of Freiburg and Basel. Eucor – The European Campus supports the consortium with the Seed Money funding instrument in the “Research and Innovation” funding line.